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The courses will take place at the Faculty of Pharmacy of Grenoble, headed by Prof Walid RACHDI. It is a teaching and research unit (UFR) that trains future pharmacists and healthcare professionals in the service of patients.

For further information, please see the Faculty of Pharmacy's website (in French only).

The EC will be based at the Institute for Advanced Biosciences (IAB) UMR Inserm U1209/CNRS U5039 /UGA within the “Epigenetic Signaling” team led by Guillermo Orsi, under the supervision of Prof. Pascal Mossuz. Prof. Pascal Mossuz heads the research group on “Metabolic and Epigenetic Interconnections in the Resistance of Hematological Malignancies.” and the laboratory of hematology at the University Hospital of Grenoble ( CHUGA)

For further information, please see the Institute for Advanced Biosciences website (IAB)

Your mission will be to teach general hematology and hemostasis to Pharmacy and Biotechnology students.

In research, your mission will be to actively participate in the research project on the impact of deregulations of the phospholipid metabolismon resistance to chemotherapy (particularly Venetoclax) in AML.

Teaching and Research Activities

Teaching Activities

Teaching activities will include:

Delivering courses in general hematology and hemostasis through lectures, tutorials, and practical sessions to:

• Pharmacy students,
• undergraduate students in the Biotechnology for Health program,
• Master’s students (M1 and M2) in Health Engineering,
• students enrolled in the Cursus Master en Ingénierie (CMI) programs,
• as well as residents enrolled in the Diploma of Specialized Studies (DES) in Medical Biology.
• Coordinating and overseeing Teaching Units (UE) within the Pharmacy curriculum (including course organization, teaching coordination, and student assessment).

Research Activities

Research activities will mainly focus on:

• The analysis of the lipidomic profile of leukemic cells according to their sensitivity to venetoclax.
• The investigation of the underlying cell death mechanisms, particularly apoptosis and ferroptosis.
• The study of the role of histone modifications in relation to metabolic variations.
• The translation of findings obtained from cell lines to patient samples, in close collaboration with the hematology laboratory.

You are expected to have the following skills:

Cell culture of leukemia cell lines derived from patients

Measurement of cell viability (FACS/apoptosis markesr/ferroptosis)

Western blot

Characterization of lipidomic profiles (interpretation of HpLC data / SIMCA software)

Study of histone acylation/acetylation modifications (Cut&run)

Analyse of gene expression variations (transcriptomics)

Correlation with clinical data of AML patients (statistical analysis/survival analysis (Kaplan Meier)